During the fourth week of embryonic life, when the embryo is between 1 and 4 mm in length, the neural plate folds bidirectionally into a tube and separates from the adjacent ectoderm. The cranial and caudal neuropores are the last areas to close and are the common sites of defects. Defects of closure are called spinal dysraphism and interfere with spinal arch morphogenesis.
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The mildest form of spinal malformation, spina bifida occulta, occurs in up to 30% of the population, is asymptomatic and may be heralded by an overlying tuft of hair, angioma, pigmented nevus or dimple.
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