A 55-year-old man presented for shortness of breath. CT scan to R/0 PE revealed a large right axillary lymph node complex. The axillary mass was easily palpable and firm with limited mobility. US-guided core biopsy showed dysplastic epithelial cells cells immunopositive for melan-A and S-100 protein and negative for E-cadhedrin, CD30 and CD45 tumor markers. A diagnosis of metastatic melanoma was made. PET-CT lit up the axillary nodes. The patient had a history of multiple basal cell carcinomas and squamous carcinoma, but not melanoma. Careful dermatological examination revealed no primary lesion on the right arm or elsewhere.