The tumor was heterogeneous with areas of both loose and dense stroma. Focal areas suggested nerve or Verocay body formation. Focal areas were suggestive of a plexiform appearance. Overt malignant features were not present.
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On permanent section, the neoplasm expressed neuron-specific enolase (NSE), S100, and glial fibrillary acidic protein (GFAP). Stains for CD34, epithelial membrane antigen (EMA) and Tyrosinase were negative. The differential included Schwannoma variants, plexiform neuroma or neurofibromatosis (ref. 1, 2 below). The patient had no evidence of neurofibromatosis, and the final diagnosis was schwannoma.
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